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Supplementation with ALA has been shown to effectively reduce serum triglyceride levels and significantly improve cardiovascular risk factors, making it a high-quality polyunsaturated fatty acid [36]
However, until a dedicated outcomes trial confirms these benefits translate to fewer heart attacks and strokes, Semaglutide remains the only option with proven cardiovascular event reduction
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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores
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